The gene for ALS? It is no longer a secret. With an international multi-center research results from the cooperation Auxologico, University of Milan and the Centro Dino Ferrari, was, in fact, identified the chromosome responsible for the particle sporadic ALS, the form of the disease in more than 90% of cases.
Fruit the collaboration of eight European countries and outside Europe (United Kingdom, United States, Holland, Ireland, Italy, France, Sweden and Belgium) the discovery, published in Lancet Neurology, is a milestone in the 'identification of genes responsible for disease and its subsequent understanding.
"Identification - says Vincent Silanes, director of the Department of Neuroscience dell'Auxologico in Milan and one of the authors of the research - has taken place with the technical Genome-Wide (GWA) to analyze, in a population of patients sporadic ALS, almost a million genetic variants in a region of 'hot' genome located on chromosome 9q21. "
The gene, as well as the Sporadic ALS, is also responsible for ALS associated with frontotemporal dementia family. The study, led by English scholars of King's College London in a series of 599 British patients with sporadic ALS and 4144 healthy controls, was confirmed in a larger series of 4321 patients with ALS and 8425 controls collected in seven different countries including Italy.
"Today's discovery - he concludes Silanes - represents a substantial step towards the definition of the etiological causes of ALS, only through these steps will be required to be established therapy for patients." IRCCS Istituto Auxologico Italian researchers have also completed the collection of DNA of 2000 Italian patients with sporadic ALS after creating a number of other Italian Centers Consortium Slagen with the intention to conduct an independent GWA study Italian.
Source: notizie.tiscali.it / articles / science
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